Case Studies

Cxbladder Detect Case Studies

The following case studies, with example data taken from the validation study,¹ highlight the clinical usefulness of Cxbladder Detect.

Gender: Male	Age: 68
Tumor Stage: pT1	NMP22 Bladder Chek result: Negative
WHO 98 grade: Low	NMP22 ELISA result:Negative
WHO 73 grade: 2	Cytology result: Negative
Risk factors: Identified high risk occupation for 40 years, smoked for 4 years
Presentation: Consulted his general practitioner complaining of dysuria (painful urination) and presenting with macro-hematuria
Summary: UC detected by Cxbladder and confirmed by flexible cystoscopy

Gender: Male	Age: 60
Tumor Stage: pT1	NMP22 Bladder Chek result: Negative
WHO 98 grade: High	NMP22 ELISA result: Positive
WHO 73 grade: 3	Cytology result: Negative
Risk factors: Identified high risk occupation for 40 years, smoked for 6 years
Presentation: Consulted his general practitioner after ongoing problems with macro-hematuria (1-3 episodes a day)
Summary: UC detected by Cxbladder and confirmed by flexible cystoscopy

Gender: Male	Age: 75
Tumor Stage: pTa	NMP22 Bladder Chek result: Positive
WHO 98 grade: Low	NMP22 ELISA result: Positive
WHO 73 grade: 2	Cytology result: Negative
Risk factors: Identified high risk occupation for 40 years, smoked for 20 years
Presentation: Presented to his general practitioner after two days of macro-hematuria
Summary: UC detected by Cxbladder and confirmed by flexible cystoscopy

The following case study highlights the clinical usefulness of Cxbladder Triage.

Gender: Male	Age: 66
History: Non-smoker, history of prostate cancer - radical prostatectomy in 2002	Cytology result: Negative
Risk factors: No history of occupational exposure
Presentation: Patient presented with chronic microhematuria.
Summary: Patient had a full workup in 2010 that was negative and a cystoscopy one year prior to current evaluation. The Low Probability Cxbladder Triage Result satisfied the patient and the urologist to forego a more extensive workup at this time. The patient's medical management plan will include routine follow-up to closely monitor his microscopic hematuria.

Last Updated: 24 Aug 2021 10:15 pm

References

¹ O'Sullivan et al: A multigene urine test for the detection and stratification of bladder cancer in patients presenting with hematuria, J Urol 2012; 188: 741-747

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